large cell lymphoma | ANAPLASTIC LYMPHOMA HAS LARGE CELLS ASSOCIATED WITH BREAST IMPLANTS

ANAPLASTIC LYMPHOMA HAS LARGE CELLS ASSOCIATED WITH BREAST IMPLANTS


1 ANAPLASTIC LYMPHOMA has large cells associated with IMPLANTS MAMMAIRESDr Alain DUVERNAY 21 AESTHETIC & reconstructive plastic surgery, the CHALON on SAONE Bank Street

2 PREAMBLE

3 preamble 30,000 women carriers of implants PIP18000 have had a 25% failing implant hull Inflammations Siliconomes Lymphadenopathy Lymphorrhees explantation

4 preamble 1 case of ALCL-AIM in France in 2011.1er global cases in 1997 monitoring: of ANSM national expert network LYMPHOPATH then new cases in France and worldwide solicitation of CNIB to constitute an expert opinion Panel experts made March 4, 2015 points of consensus among experts

6 analysis of the cases of ALCL - Immuno-operational Aimcaracterisation: constant Expression of the CD30 Phenotype T cytotoxic Absence of KLA Double reading pathological network lymphopath

9 analysis of cases of ALCL - AIM features Cliniquesserome with adenopathy

10 estimate of the risk of the ALCL - AIMLien between ALCL and clear Breast Implants but complication of low impact: estimated impact accumulated between 1 and 2 / patients for 10 years so little impact: risk factors not identified formally many missing data bias ++ but it seems that the macrotexturation is involved with induction of inflammation Genetic Predisposition? role of periprothetique biofilm?

11 C.A.T. on suspicion of ALCL-AIMEpanchement fluid late > 1 year after the breast volume increase pain Inflammation, mass, ulceration, AEG signs alert

C.A.T. 13 in case of suspicion of ALCL-AIMIRM in second intention: If non-contributory ultrasound

C.A.T. 14 on suspicion of ALCL-AIMSi fluid effusion: make a Fna study cytological study molecular immuno-phenotypic study

C.A.T. 15 on suspicion of ALCL AIMSi mass and/or adenopathy satellite: an Etudehistologique study biopsy immuno-phenotypic Molecular study

C.A.T. 17 in case of confirmed diagnosis of ALCL-AIMConsultation hematologist assessment of extension of lymphoma statement materiovigilance ANSM once the confirmed diagnosis of the RCP report

18 C.A.T. diagnosis confirmed ALCL-AIMQuelque or the stage of the disease at diagnosis: Explantation + Capsulectomy total bilateral not of relocation

C.A.T. 19 in case of confirmed diagnosis of ALCL-AIMRCP

20 monitoring and Information of female carriers of ALCL-AIMFemme implants asymptomatic clinical examination  annual ultrasound? Integrated in the Backgrounder information. Consent

21 thank you for your attention