diffuse large b cell lymphoma treatment | Treatment of diffuse Lymphoma large cell b in children

Treatment of diffuse Lymphoma large cell b in children

In the presence of diffuse Lymphoma large cell B (DLBCL) in children, can be used in the following treatment options. The care team will suggest treatments that are based on the needs of your child and will work closely with you to develop a treatment plan. Treatments are often based on the stage of the cancer or the risk category.

First line treatment of DLBCL in childrenThe first line of treatment is the treatment which is used first or most commonly. The following treatments may be given as first line treatment for diffuse Lymphoma large cell B (DLBCL) in children.

SurgeryIn general, a surgeon a surgical biopsy (open) to establish the diagnosis. In rare cases, if the lymphoma hit one region of the body such as the abdomen, we can practice a surgery to remove the lymphoma before administering chemotherapy.

ChemotherapyChemotherapy is the main treatment for diffuse Lymphoma large cell B (DLBCL) in children. The duration of chemotherapy depends on the category of risk and the treatment plan (Protocol). Chemotherapy may be given for 9 weeks to 6 months for a stage 1 or 2 DLBCL and for 6-8 months for DLBCL of stage 3 or 4.

Chemotherapeutic agents are administered according to various associations based on different treatment plans. The following chemotherapeutic agents are most commonly administered according to different associations for DLBCL:

cyclophosphamide (Cytoxan, Procytox)
Vincristine (Oncovin)
prednisone
cytarabine (Cytosar, Ara - C)
etoposide (Vepesid, VP-16)
methotrexate
prednisolone
doxorubicin (Adriamycin)
hydrocortisone
dexamethasone (Decadron, Dexasone)
Daunorubicin (Cerubidine, daunomycine)
L-asparaginase (Kidrolase)
Mercaptopurine (Purinethol, 6 - MP)
thioguanine (Lanvis, 6-TG)
Intrathecal chemotherapy may be given to prevent the NHL from spreading to the brain and spinal cord (central nervous system, CNS) or to treat an NHL that has spread until the SNC. This means that drugs are administered directly into the cerebrospinal fluid (CSF) around the brain and spinal cord. Intrathecal chemotherapy may include the administration of 1 to 3 of the following chemotherapeutic agents:

methotrexate
cytarabine
hydrocortisone
DLBCL relapsing in children
Treatment of diffuse Lymphoma large cell B (DLBCL) Relapsing in children may include more intensive chemotherapy, with or without treatment, or Allogenic or Autologous stem cell transplant.

The following chemotherapeutic associations are administered to treat DLBCL relapsing in children:

dexamethasone, etoposide, cisplatin (Platinol AQ), cytarabine and asparaginase
ifosfamide (Ifex), carboplatin (Paraplatin, Paraplatin-AQ), etoposide and rituximab (Rituxan)
Clinical trials
Many children with lymphoma diffuse large cell B (DLBCL) are treated in a clinical trial designed according to the category of risk or the stage of their disease. The plan or clinical trial protocol, says treatments (such as chemotherapy or targeted therapy) as well as the dosages and chemotherapeutic agents that will be administered. Learn more about clinical trials.