large b cell lymphoma stage 4 | Primitive diffuse large B-cell Lymphoma of the transverse colon

Primitive diffuse large B-cell Lymphoma of the transverse colon


Summary
Localization extranodaux no hodgkiniens primitive lymphomas FAP is rare and represents only 10-20% of gastrointestinal lymphomas and 0.2-0.6% of colorectal malignancies. We report the observation of a 84 year old man who was hospitalized for exploration of constipation with abdominal pain. Colonoscopy showed a ulcerated lesion in the transverse colon which biopsies had concluded that a B-cell lymphoma large cell. The MTR extension was negative. The patient died after three courses of chemotherapy. Through this observation and a literature review, we will discuss the epidemiologic features, clinicomorphologiques and treatment of this rare entity.

Key words
No extranodal lymphoma Hodgkin Lymphoma chemotherapy Colon Diffuse large B-cell lymphoma of the transverse colon
Abstract
Localization of primitive Rectocolonic extranodal non-Hodgkin lymphoma remains rare. It accounts for only 10-20% of gastrointestinal lymphomas and 0.2-0.6% of colorectal malignancies. We report the case of a patient aged 84 years who was admitted for exploration of constipation with abdominal pain. Colonoscopy revealed year ulcerated lesion of the transverse colon. Histological examination revealed a diffuse large B-cell lymphoma. The staging was negative. The patient died after three cycles of chemotherapy. Through this observation and the literature review, we discuss the epidemiological and clinical-morphological features and treatment of this rare entity. To cite this journal: Acta Endosc.

Keywords
Non-Hodgkin lymphoma, Extranodal lymphoma Chemotherapy Colon


Primitive diffuse large B-cell Lymphoma of the transverse colon
Diffuse large B-cell lymphoma of the transverse colon
L. Mnif · Mr. Medhioub · A. Amouri · L. Chtourou · Mr. bitch · N. Tahri
© Springer-Verlag France 2012
Summary location lymphomas not FAP
extranodaux primitive hodgkiniens is rare and does not represent
that 10-20% of gastrointestinal lymphomas and
0.2-0.6% of colorectal malignancies. We report
the observation of an 84 year old man who was hospitalized
for exploration of constipation with pain
abdominal. Colonoscopy showed a ulcerated lesion
transverse colon which biopsies had concluded that a
B-cell lymphoma large cell. The MTR extension was
negative. The patient died after three courses of chemotherapy.
Through this observation and a literature review.
We will discuss the epidemiological characteristics,
clinicomorphologiques and treatment of this
rare entity. To cite this journal: Acta Endosc. 42 (2012).
Keywords not · Hodgkin Lymphoma Lymphoma
extranodal · Colon · Chemotherapy
Abstract Rectocolonic localization of primitive extranodal
non-Hodgkin lymphoma remains rare. It accounts for only
10 20% of gastrointestinal lymphomas and 0.2-0.6% of
Colorectal malignancies. We report the case of a patient aged
84 years who was admitted for exploration of constipation
with abdominal pain. Colonoscopy revealed year ulcerated
lesion of the transverse colon. Histological examination
revealed a diffuse large B-cell lymphoma. The staging was
negative. The patient died after three cycles of chemotherapy.
Through this observation and the literature review.
We discuss the epidemiological and clinical-morphological
features and treatment of this rare entity. To quote this
Journal: Acta Endosc. 42 (2012).
Keywords-Non-Hodgkin's lymphoma · Extranodal
Lymphoma · Colon · Agents and chemotherapy
Introduction
Extranodaux no primitive hodgkiniens lymphomas are
rare tumors. They affect the gastrointestinal tract
in 40% of cases. However, the colic achievement remains rare
noted only in 10-20% of cases and does not represent
only 0.2 to 0.6% of colorectal malignant tumors [1,2].
We report a new case of primitive Lymphoma
colic and we discuss through this observation and
a the literature review the epidemiological characteristics.
clinicomorphologique and treatment of this entity
rare.
Observation
A man aged 84, no pathological history
Special, was admitted for exploration of constipation
with unusual abdominal pain moving from two
months. Review at admission was without anomalies. The
patient had a condition retained without loss of weight;
BMI was at 21. The abdomen was soft, movable, painless
without palpable mass or visceromegalie. The review of the
anal margin and Dre were normal. Areas
ganglion were free. The biological assessment showed
macrocytic to 9.6 g/dl normocytic anemia and a syndrome
inflammatory biological VS to 60 mm/1 h; CRP to
47 mg/l. White blood cells were 7 420 E / mm3 and the
338 000 E platelets / mm3
. The LDH were 274 IU/l. The
dosage of beta2-microglobulin has not been done. The rate
of the total protein was 71 g/l with hyper-α1-, α2 -, and
gammaglobulinemie to 6.5, 13.2 and 22.6 g/l respectively.
Colonoscopy showed the presence at the level of the colon
transverse broad 2 cm of great substance loss
at bottom Nodular axis, bead regular, stiff to palpation
Endoscopic (Fig. 1). Biopsies have been preserved
in formaldehyde and concluded to a B-cell lymphoma to large
cells showing a round of cell proliferation
size medium or large reduced cytoplasm and nucleus
round or oval hyperchromatique regular, nucleolus. The index
L. Mnif (*) · Mr. Medhioub · A. Amouri · L. Chtourou ·

Mr. bitch · N. Tahri
Mobile service,
CHU Hédi-Chaker, road El - Ain, 3029 Sfax, Tunisia
e-mail: leilamnif@yahoo.fr
ACTA Endosc. (2012) 42:123 - 125
DOI 10.1007/s10190-012-0235-7
mitotic was high. At IMMUNOHISTOCHEMISTRY, tumor
was positive for anti-CD20 and CD45 CD79a with a
score of the high Ki67 expression. As part of the
extension of his illness, fibroscopy oesogastroduodenale
showed an aspect of extrinsic compression to the
level of the cave (Fig. 2). Biopsies concluded that gastritis
chronic follicular antrofundique no atrohique to
Helicobacter pylori without intestinal metaplasia. The scanner
best-abdominal-pelvic had concluded that the presence of a
circumferential transverse colonic wall thickening
juxtaposed to a magma of Lymphadenopathy 65 × 22 mm of
main areas that repress the gastric antrum. There is not
any other deep Lymphadenopathy or other visceral anomalies.
The enteroscanner showed no other locations
digestive. The biopsy osteomedullaire, review
ORL and biopsies of the cavum were without anomalies. The
diagnosis was that of B-cell lymphoma large cell
primitive of the colon. Compared to advanced patient, surgery
has not been indicated and chemotherapy
(CHOP) was proposed. He benefited from three cures, which
were well tolerated but the patient died at the end of the
fifth month of follow-up.
Discussion
The FAP of lymphomas no hodgkiniens location
extranodaux primitive is rare and does not represent that
10 20% of gastrointestinal lymphomas [1]. The diagnosis
requires the absence of systemic damage. Indeed
in 1961, Dawson and al. [3] were the first to establish a
diagnostic criteria for the disease:
• absence of peripheral lymphadenopathy;
• lack of Mediastinal lymphadenopathy in radiography
thorax;
• lack of hematological abnormalities with a biopsy
normal osteomedullaire;
• during a laparotomy, only local lymph
are affected;
• liver and spleen are healthy.
This type of lymphoma affect predilection topics
between the fifth and the seventh decade with an average age
at the time of the diagnosis of 55 years. The men are two
times more affected than women [4]. The etiology
remains unknown. However, a high frequency is denoted
in the immunosuppressed such that during illness
inflammatory Chronicles of intestine, HIV
and after organ transplantation [1].