large b cell lymphoma | Colonic diffuse large B-cell lymphoma mimicking metastatic carcinoma

Colonic diffuse large B-cell lymphoma mimicking metastatic carcinoma


Summary
The primitive non-hodgkiniens (NHL) lymphomas of the colon represent only 0.4% of colon cancers. They are usually isolated from clinical stage I or II, phenotype B, the treatment of choice remaining adjuvant chemotherapy followed by surgery. In the more advanced stages, the usual secondary locations of NHL are ganglion, splenic and/or spinal cord. We report unusual clinical presentation of a NHL diffuse large B-cell, whose mode of extension was carcinomateuse look, with secondary locations liver and ovarian. This observation should alert clinicians on the fact that a colonic tumor, even with such a mode of expansion, can be a NHL and histological diagnosis must absolutely be obtained prior to any treatment. Indeed, the prognosis with colic, even metastatic NHL, will be better than an adenocarcinoma.

Summary
Primary colonic nonhodgkin lymphoma (NHL) accounts for only 0.4% of all malignant neoplasms GI [4]. NHL is usually locoregional, clinical stage I or II, Bcell lineage and surgical resection with adjuvant chemotherapy is the treatment of choice. Advanced NHL has lymphatic spread, with nodal lymphomatous, spleen and/or done marrow involvement. We report a case of diffuse broad Bcell NHL with unusual clinical presentation. Metastatic spread was carcinomatouslike with liver and ovarian secondary nodules. Our observation must alert clinicians to colony tumors with this kind of spread spread. NHL can be a differential diagnosis and histological diagnosis must be performed before treatment. Prognosis of NHL, even with metastatic extension, will be better than prognosis of S3.

Keywords
broadcast metastatic Lymphoma Lymphoma diffuse large cell B Keywords colic
colony lymphoma diffuse large B-Cell lymphoma metastatic spread


Diffuse Lymphoma / I simulating large cell B of the c61on
Carcinoma m6tastatique

RI ~ SUMI ~.
The primitive non-hodgkiniens (NHL) lymphomas of the c61on don't represent 0.4% of colon cancers. They are usually
isol6s, clinical stage I or II, of ph6notype B, the treatment of choice remaining surgery followed by a chimioth6rapie adjuvant. In the
more avanc6s, the usual secondary locations of NHL stadiums are ganglion, spl6niques and/or m6dullaires. We report the
unusual clinical pr6sentation with diffuse NHL ~ t large B cells, including the mode of extension 6tait of carcinomateuse, with pace
locations secondary h6patiques and ovarian. This observation should alert the clinician to the fact that a colonic tumor, mSme with
such way of extension, can 8tre NHL and that the histological diagnosis should absolutely 8tre obtained prior to any treatment. Indeed, the
prognosis of a colonic NHL, mSme m6tastatique, will be better than an ad6nocarcinome.
SUMMARY
Primary colonic non-hodgkin lymphoma (NHL) accounts for only 0.4% o fall Gl malignant neoplasms [4]. NHL is usually locoregional,
Clinical internship I or I1, B-cell lineage and surgical resection with adjuvant chemotherapy is the treatment of choice. Advanced NHL has lymphatic
lymphomatous spread, with nodal, spleen and ~ gold done marrow involvement. We report a case of diffuse large B-cell NHL with unusual clinical
presentation. Metastatic spread was carcinomatous-like with liver and ovarian secondary nodules. Our observation must alert clinicians to
colonic tumors with this kind of spread spread. NHL can be a differential diagnosis and histological diagnosis must be performed before
treatment. Prognosis of NHL, even with metastatic extension, will be better than prognosis of S3.
INTROD INTRODUCTION
Extranodaux non-hodgkiniens (NHL) lymphomas
are rare tumors. The gastrointestinal tract
is the most common site, between 30 and 50%
extra-nodaux NHL affecting the digestive system
[1-3]. N6anmoins, these primitive NHL digestive don't
repr6sentent 1 ~ 4% of digestive cancers [1]. Them
locations the most fr6quentes are the stomach and
intestine gr61e, colorectal achieve not repr6sentant
10 ~ 20% of cases [1].
OBSERVATION
A woman of 60 years, in the family ant6c6dents
of breast cancer (his m6re and two other members of)
his family), consulted for the flank pain
law 6voluant for several months. The patient
was an alt6ration of the g6n6ral 6tat, and palpation
the ditch right iliac objectivait a mass
r6nitente. The scan abdominal r6v61ait a large
mass of the il6o-c r6gion ~ hulls and three macronodules
hypodenses h6patiques (Fig. 1). Colonoscopy
found a 16sion c ~ st6nosante hulls, but the
biopsies pratiqu6es 6taient n6gatives. Three weeks
Apr ~ s the premi6re consultation, the appearance of a syndrome
Occlusive led ~ a laparotomy. One
right colectomy 6tait r6alis6e, associ6e has a r6section
partial h6patique, and ~ a right oophorectomy
(d6cision per op6ratoire for a tumor appearance
m6connu Imaging).
The macroscopic appearance of the pi6ces diff6rentes
op6ratoires 6tait all h done for Carcinoma
(Fig. 2). The large tumor il6o-c ~ 13 cm hull
6 on 3, massively infiltrating the intestinal wall.
6tait associ6e h 3 ad6nopathies locor6gionales
appearance m6tastatique. Ovarian 6tait almost right