follicular lymphoma | Follicular Lymphoma FAQ

Follicular Lymphoma FAQ

Here are the main issues that matter most to the realization of long-term survival in good health with follicular lymphoma. Please be sure to see the natural (spontaneous) cover regression.

After reviewing the FAQs below, read the Basic Concepts Page receive vital "big picture" knowledge re confusion, controversial nature of follicular lymphoma.

See our home page for tips on Lymphoma 4Programme P - GRS survival, considered to be essential for health and vitality long term to 20 years.

1. Is likely to be found for follicular Lymphoma medicine?
A permanent cure for any form of cancer requires a correction of defective genetic signalling.

Drugs, new and old are able to kill a number of malignant cells. For this purpose, they are useful and often critical (when vouchers are used at the right time) for many survivors. but the treatments (including radiation and immunotherapy) cannot repair genetic mutations or ongoing daily imbalances in gene expression. So, unfortunately, the benefits of treatment are temporary only to relapse being common. Follicular lymphoma is incurable.

However, many things can be done in addition to standard treatments. When it is properly implemented, these initiatives can greatly extend the time of survival of follicular Lymphoma, while simultaneously allowing the survivor to live a healthy life, free of the active life of the side effects.

Details on our four pillar of restoring Gene (4 p - GRS) programme strategies are covered in the FAQ 11 ~ 14 below.

The path to healing page will be a source of inspiration in this regard.

2. do all patients with lymphoma follicular need treatment?
In the current context, more than one (fNHL) Follicular Lymphoma survivors require conventional treatment at some point, but not necessarily at the time of diagnosis. (See #3 below for). If it becomes necessary, it is very important that these treatments are chosen wisely and properly applied in consultation with its clinical oncologist. We provide information covering the various treatment options, new and old. We have an article on optimization of chemotherapy and another on nutritional Strategies during and after treatment.

Many Members here have not need treatment for 10 years and more. Many have experienced spontaneous (natural) regression. See FAQ below #10 of.

3. when a patient of follicular Lymphoma know what he or she needs treatment?
New research shows that nearly 75 percent of survivors newly diagnosed should be "watched" or followed the "active surveillance" (in which 2018 is more common in prostate cancer). The other 25% would benefit from early treatment.

New diagnostic survivors should familiarize themselves with these data on who should be treated quickly and can delay treatment until more later (if necessary in East).

In general, the time to deal with is when lymphoma starts to interfere with the normal activities of one, such as pain or not feeling well, or for aesthetic or psychological reasons.

4. I'm on chemo and look forward to rituximab maintenance after to stop my cancer to come back. My doctor changed his mind and said more Rituxin is not a good idea. Should I seek a second opinion?

Not. You are lucky to have a good doctor. She has probably read recent information of prominent specialists indicating that maintenance rituximab is now regarded as optional since it does not increase overall survival time and often leads to severe immunosuppression After.

In response to many questions concerning us in that rituximab maintenance, we have prepared a summary of the advantages and disadvantages. It includes several quotations from eminent specialists.

As a member of the lymphoma survival group, you can request a copy of this summary by e-mail at Robert@LymphomaSurvival.com Type MR summary request in the subject line.

Problems with rituximab for maintenance will probably also be applicable to Gazyva (obinutuzumab) and so called "Biosimilars" to rituximab which are now becoming available. Details about the newsletter are available here.

This should help you to understand the current concerns and make the right choice in consultation with your doctor.

IMPORTANT update: Four doctors of leading Lymphoma now reported officially, quote: "MR cannot be recommended as a standard for the treatment of the FL". This may finally mark the end of M.. If the RM, or plan to do so, you should be aware of this development for the follow-up of the discussions with your doctor. More information is available on our site.

5. I'm confused about the conventional therapy and so-called alternatives. -What are the alternatives really work?

A new field of medicine has become known as Epigenetics. Certain characteristics of alternative medicine, impossible, can now be identified with one degree of accuracy of specific genes in Lymphoma training (and other cancers). Research linking lifestyle practices to the expression of the genes has advanced quickly.

See FAQ 11 ~ 14 below for more details on our four pillar of restoration strategies Gene (4 p - GRS) program. Please also review our chart Lymphoma follicular page.

6. as follicular lymphoma is considered to be incurable, why can't the same treatments take over and over again?

Everyone becomes resistant to the repeated use of the same chemotherapy drugs, including monoclonal antibodies such as rituximab and obinutuzumab (Gazyva).

New drugs such as Ibrutinib and idelalisib (Zydelig), including some immunotherapies T cells (still in trial) are intended for continuous use. However, as expected, early indications are that the resistance is fixed with the accumulation of side effects, causing the normal cell population of the victim to a malfunction.

[Note: Ibrutinib and idelalisib (Zydelig) have now been abandoned in many applications, mainly due to "off-target" serious side effects].

The best way to work around this problem is to improve the health of our normal cell population. Search back to 2004 indicates that the tumor "microenvironnement" survival is the main determinant of the duration of overall survival with follicular Lymphoma, not treatment. "

A micro-environment "sain" results from the creation of the favorable gene expression in normal cells. "

Watch for new developments on our website in the coming weeks towards the creation of a favorable Tumor Microenvironment to encourage the natural regression. See FAQ below #10 of.

7. why you insist you need for long - long term planning for 20 + years of active and healthy survival?

As long as follicular Lymphoma remains incurable and that all conventional treatments develop resistance during repeated use, it is very important to use the limited treatment carefully and only when needed . Some treatments, such as those for processing, can be used only once.

The patient, as Managing Director of its case, must take account of all the information on the treatments available in the plan total based on the latest scientific research covered in depth on our site to make decisions treatment.

The survivor informed the most likely to succeed is the survivor who can choose treatments and strategically if necessary in consultation with their doctor-> and then follow up with one program scientifically recovery; From there, past to extended, survival in good health as the ultimate goal.

8. What is the main barrier to block long - long term with follicular Lymphoma survival?

Transformation. processing all follicular Lymphoma survivors should be fully aware and knowledgeable about.

Transformation refers to a certain but not all of the follicular lymphoma cells become aggressive. The transformation is a confusing question, often misdiagnosed. The treatment is usually necessary. The complexity of diagnose and treat this serious event, provide us survivors of the information detailed on the transformation.

It is very important to get the benefits of a treatment at this time. We have "strategies of chimio optimization" in article #8 and article #9 we cover what you need to know to optimize feeding and promote healing and recovery during and after treatment. "

9. is at - it new conventional treatments on the horizon for the treatment of follicular Lymphoma?

Yes. They are very different than in years past.

Other than for work on the reformulating of platinum-based chemotherapy (which we support) to make them less toxic, virtually all the research on the chemotherapy has stopped.

Nanotechnology, still in its early stages, is very promising.

In accordance with the genetic 'revolution', research in recent years for follicular Lymphoma focused on drugs of genes such as Ibrutinib (Imbruvica), idelalisib (Zydelig) and ABT-199 (Venetoclax). more recently on duvalisib, copanlisib, tazemetosat and others.

Some of the drugs mentioned above, yet tested in clinical trials, are not yet approved for use in patients with follicular Lymphoma, or are approved only for patients in relapse. The approval status of these new drugs made from genes is changing rapidly. Approval usually comes first in the United States.

Overall, on the basis of data of trials so far, we see obvious problems with these drugs at base of genes both with regard to their initial effectiveness, sustainability and particularly targets out cumulative effects secondary resulting from having to take them on a basis never stop. The cost can exceed US $100,000 a year, sometimes a lot more.

Details on these gene-based drugs are treated in various recent newsletters. We strongly recommend that survivors interested by these drugs see our Index of subjects and recently updated Article #6, when dealing with and with which Relapse treatments including.

[Note: Ibrutinib and idelalisib (Zydelig) have now been abandoned in many applications, mainly because of serious side effects off target].

In 2018, the appeal of these closely targeted gene-based drugs seems to be declining.

There are currently a lot of publicity about immunotherapy for Lymphoma (blocking PD and as - T). Trials are underway. These drugs, if approved, will be probably for patients who relapsed last resort (rescue therapy) which are not considered new adaptable conventional therapies, including stem-cell transplants. Expect frequent, often serious side effects, coupled with horrible cost, probably to the subject $450,000 with a time as - T and $150,000 / year, in some current cases (as with the PD inhibitors).

[New information about immunotherapy is moving quickly. Currently, it is difficult to get the balance, data not biased on CAR - T from reliable sources. Those interested should study more, using terms of research such as the pros, cons, immunotherapy, cart, follicular lymphoma].

10. you talk about "spontaneous regression" with follicular lymphoma. What is it?

All follicular Lymphoma survivors should be fully informed about spontaneous (natural) regression.

Spontaneous regression, also known as the natural regression means lymphoma starts to turn and to contract in the absence of a conventional treatment. The word "spontaneous" implies that this reversal occurs, "hors of the bleu", for an unknown reason. " We do not agree - natural regression is the predictable result of what happens when the expression of the defective genes in Lymphoma conduct is brought back in balance. This is accomplished by applying strategies for remediation of the genes.

natural regression may occur at any time in his trip with follicular Lymphoma - both before and after treatment. Once this happens, it is usually standing in this place.

Years of experience indicate that the survivors of follicular Lymphoma who undergo a natural regression have a much better long term perspective. Read what Members saying page for comments from members who have experienced a natural decline as a result of the application of our 4 p - GRS program.

Now we see that it is possible to extend the permanent removal of a node with lymphoma unique to all nodes. This ongoing process over an extended period may lead to a possible resolution of the disorder.

[Note: Regression and fitness are two different things.] Remission is a clinical term, referring to a period of time during which the lymphoma is "repos", requiring no treatment. "

Also note that natural resources (spontaneous) regression and frequency of the so-called "grow and decrease" are not the same thing. The regression is generally stable in a specific location.]

11. what exactly is this 4 p - GRS program you have here?

FAQ #5 rated research linking lifestyle to the expression of the genes in the human body.

For general information, all humans have the same genes. It is therefore not a question of having a gene or not to have. It is so-called "option" in a gene that make us all different.

In addition, and just as important, if not more, it is the expression of our genes (known as Epigenetics) which is regulated or to the low 24/7 based largely on lifestyle habits and environmental exposures.

When things in our lives are in balance, our bodies much (wonderful) the means to regulate the growth of the cancer and even to repair faulty DNA in our genes. (powerful stuff!).

By applying the latest research linking lifestyle to optimal gene expression as precisely as possible, our four pillar Gene Remediation (4 p - GRS) program was developed. #3, 10 and 11 contain recommendations on nutrition, diet, exercise, sleep, managing stress and optimal year-round vitamin D.

The program 4 p - GRS is sound and biologically, powerful and flexible. The focus is at any time on the balance and quality of life. It is now available for the first time for adoption by proactive survivors of follicular lymphoma.

12 do you mean that all what I have to do is apply the 4 p - GRS program and do not consider conventional treatments?

No, not at all. Knowledge of two conventional treatment options and natural science-based strategies provides survivors with the best chance to carry out prolonged, healthy survival off spent 20 years without effects in course.

13. how much time does take before a survivor experiences visible results after the adoption of the programme 4 p - GRS?

It is very variable, as might be expected, based on many personal factors that are different from one patient to the other. It is likely that, with a full adoption of the suggestions in the articles 3, 10 and 11 and the initial benefits should appear after three months.

14. How have you developed your "four pillars" natural strategies program for reorganization of the gene?
As other survivors will understand, it is a shock to learn about diagnosed follicular lymphoma is clinically incurable with a median survival of 10 ~ 12 years old.

After my diagnosis in 1988, it was obvious that "look and attendre" - just go home until things get worse - was nothing more than a form of benign neglect. "." Totally unsuitable! Opt for aggressive treatment, trying to blow, blindly go to a treatment that had never reached her would be even worse.

So I read the research on follicular Lymphoma, spending many hours in medical libraries. Then one day, the most incredible thing jumped:

Research from Stanford University in 1984 showed that 80% of follicular Lymphoma survivors were still alive spent over 15 years, not treatments, but the treatment by the restraint. Not only that, but about a third had experienced spontaneous (natural) regression.

More than anything in the world, the data gave me the hope of a source that I could count on. He was in the New England Journal of Medicine. beliefs generally that overall survival time was only in the 10 range of the year (still held to be true in many quarters) was "pas quite exact"! "

For the first ten years after my diagnosis my interest in natural strategies grew as I was determined to do whatever I could to help myself and to increase my chances to live healthy prolonged survival.

With the advent of the Internet, LymphomaSurvival look shape in 1999. She has focused on the ideas and suggestions on what I had learned over the years regarding both natural strategies and treatment considerations.

Until about 2008, a lot of my natural strategies have been developed from the field of alternative medicine. Hundreds of options are available. There were a few new ideas (714 X, hydrazine sulfate, IV vitamin C, NDA, ++ >), but many others were simply reports of folklore developed over the decades. Some of the advice of alternative medicine seems to help, but most have not. You learn, and we hope to live again.

Fast forward to about 2010; now a different point of view of cancer emerges from research performed mainly by geneticists and biochemists. This new research has revealed that cancer occurs not only because of "bad luck". Cancer is a genetic disease that is regulated in part by initial mutations, but most of the time by the expression of the gene of the diagnosis. As a result, our natural strategies program has changed to include new research.

In 2014 we have changed the name of our program of targeted natural strategies (TNS) to the four pillar of restoration strategies Gene (4 p - GRS) program.